Clinical analysis of treatment outcomes in women with infertility against the background of polycystic ovaries syndrome and chronic endometritis

Introduction. In women with polycystic ovary syndrome, infertility is a serious and urgent problem, which caused not only by anovulatory menstrual cycles [1], but also changes in the histological structure of endometrium, adversely affects embryo implantation subsequent pregnancy. Thus, chronic endometritis syndrome are among causative factors repeated unsuccessful assisted reproductive technology (ART) programs [2-3].
 Aim study. To analyze clinical outcomes patients against background PCOS (CE) ART protocols, depending on treatment scheme.
 Materials, methods their discussion. The study included 140 CE. Study group I comprised 43 CE, who were offered conventional for endometritis. II 63 treated using modified scheme that additionally alpha-lipoic acid, endometrial plasma therapy lipid infusions (to reduce cytotoxicity) day frozen transfer (FET). both groups, delayed was performed cryocycles after 2-4 months. Cryoprotocols HRT NC. control 35 due to male causes.
 Results Comparing causes we found no significant differences between groups. There difference groups frequency surgical interventions anamnesis patients. It should be noted, however, first second dominated IUDs (respectively, 18.60% 19.35% cases) relative (2.86%). records show scraping uterine cavity walls laparoscopy, these values do significantly differ from group. Hysteroscopy 13.95% 12.90% II, higher compared (8.57%). Laparotomies least frequent type intervention picture inflammatory disorders asymptomatic course, pelvic pain, sexual dysfunction, vaginal discharge. addition comorbid CE had high discharge 62.79% 56.45% patients) pain (30.23% 33.87%, respectively), than results Notably, combined (comprising II), course more timely (p = 0.025).
 Conclusions. this indicate suffering scleropolycystosis prone ascending infection dysregulation microbial environment, ultimately becomes factor process has an extremely negative effect Endometritis can linked through metabolic endocrine pathologies.